SB 5201 Langerhans cell histiocytosis

Diagnostic Talley: Histiocytosis—2, granulomatous disease—25, Crohn’s—1.

IPOX: CD68(+), S100(+), CD1a(+).

SB 5202 Histoplasmosis + Candidiasis

Diagnostic Talley: Histoplasmosis + Candida infection—unanimous.

Cultures positive for above organisms.

SB 5203 Intravascular ALK-1 (+) anaplastic large cell lymphoma

Diagnostic Talley: Rosai-Dorfman disease—5, inflammatory lesion—2, intravascular lymphoma—15.

IPOX: CD30 (+), ALK-1(+), CD2(-), CD56(-), CD79a(-), EBV(-).

SB 5204 Acinar cell carcinoma

Diagnostic Talley: Large cell NE carcinoma—10, acinar cell carcinoma—10, mixed acinar+endocrine carcinoma—3.

IPOX: A1ACT (focally +), all neuroendocrine and peptide hormone markers negative.

SB 5205 Neuroendocrine cells within adipose tissue, favor heterotopic pancreas but can not rule out carcinoid (primary vs metastatic).

IPOX: Chromogranin (+), synaptophysin (+), pankeratin (+).

Diagnostic Talley: Vascular malformation—3, NE tumorlets—5.

SB 5206 Extramedullary myeloid cell tumor, consistent with acute myeloid leukemia with abnormal eosinophils.

Diagnostic Tally: Granulocytic sarcoma—20, lymphoma—2.

IPOX: MPO(+), CD34 (subset of blasts +), CD19 (-), CD56 (-),

SB 5207 Metastatic melanoma, primary site unknown

Diagnostic tally: Melanoma—unanimous.

SB 5208 Prostatic stromal proliferation consistent with low grade spindle cell neoplasm.

Diagnostic Tally: Solitary fibrous tumor—5, stromal hyperplasia secondary to Finasteride therapy—20.

IPOX: CD34, keratin cocktail, SMA, S100, Ki-67 (all negative).

Consultants: Stanford: Low grade spindle cell neoplasm. AFIP: Stromal hyperplasia.

Reference: Yoichi K, et al. Acta Urol Japonica. 51(12); 843-847, 2005.

SB 5209 Parathyroid adenoma, water clear cell variant

Diagnostic Talley: Parathyroid adenoma, water clear cell variant—unanimous.

SB 5210 Glomangiopericytoma

Diagnostic Talley: Hemangioma—2, spindle cell myoepithelioma—1, monophasic synovial sarcoma—2, glomangiopericytoma—25.