4880: Primary histiocytic sarcoma of the CNS
IPOX: Vim+, CD68+, lysozyme+, S-100 minimal +, CD1A-, GFAP-, NSE-, NF-, CD21-, CD117-, ALK-, keratins-, CD3-, CD20-, LCA-, CD30-
Ref: Pileri et al. Histopathology 2002,41, 1-29
4881: Anaplastic chordoma
IPOX: Subpopulation of cells are immunoreactive for S100. INI-1 reactivity is equivocal. The neoplastic cells are non-reactive for alkaline phosphatase, E-HCG, myogenin, desmin, MSA and SMA. Electron microscopy reveals cytoplasmic vacuoles in some of the neoplastic cells.
Ref: Coffin et al. Chordoma in Childhood and Adolescence. Arch Pathol Lab Med 117:927-933, 1993.
4882: Paraganglioma with dense sclerosis
IPOX: Synaptophysin (+), S100 (sustentacular cells +)
4883: Synovial sarcoma
IPOX: Vim(+), AE1/AE3 and Cam5.2 (+; weak to moderate), CK7(+), EMA(+), S100(-), desmin(-), actin(-)
Consultant: Stanford pathology
4884: Highly atypical fibrohistiocytic lesion, favor AFX
IPOX: Vim(+), S-100(-), CK5/6(-), desmin(-).
Consultant: Stanford pathology
4885: Granulomatous pneumocystis pneumonia
GMS and IPOX reveal rare organisms consistent with PCP
Consultant: Mayo clinic
4886: Transitional cell carcinoma and atypical serous tumor
Consultant: UCSF pathology
4887: Small lymphocytic lymphoma with plasmacytoid features and crystalline inclusions
Flow cytometry: 80% kappa, 0% lambda, 85% CD19, 95% CD38, 55% CD23,
90% FMC-7, CD138 0%. IPOX: kappa light chain (+)
4888: Basal cell carcinoma with stromal giant cells
IPOX: BCC positive for CK, SMA, bcl-2. Stromal giant cells bcl-2 positive.
Ref: Am J Dermpath 1999, 21:473.
4889: Metastatic squamous cell carcinoma with differing morphologic features
IPOX: a) SCC: CK5/6(+), p63(+), chromogranin (-), synapto (-), LCA(-).
b) Anaplastic tumor (node): CK5/6(+), p63(+), chromo, synapto and LCA (-).